Ayurveda the wholistic science deals with ashtangas. Hridaya one among trimarma also plays important role in the body as chetanasthana, koshtanga, ojosthana likewise. Agadtantra is one of the branch emerged as emergency medicine which manages the poisoning cases. Hridayavarana is a wide concept described under this Agadtantra branch for the removal of poison from the body. This article highlights the theoretical concepts of hridayavarana in cardioprotective and oncology preventive aspect.