Dermatopathological investigation of stephanofilariasis involved examination of 1,427 cattle maintained under the traditional husbandry conditions of dairy farms at Birgonj Upazila, Dinajpur in Bangladesh. The investigation was carried out among 381 humpsore affecting cattle. Very close visual inspection and palpation of the entire skin surface of the body were the commonly adopted clinical methods of examination of the animals. The clinical and pathological features including topographic positions of the lesions as well as complications were also recorded. The skins of 3 typically affected cattle were collected, preserved, processed, embedded with paraffin, sectioned and stained with hematoxylin and eosin for the histopathological study. Crusts including the worm were examined in the parasitology laboratory for the identification of Stephanofilaria spp. Stephanophilariasis was therapeutically managed through injecting ivermectin and also the application of an ointment prepared with zinc, Potassium iodide, Methylene blue and Vaseline in an appropriate ratio. The highest incidence was recorded in the dairy farm (31.63%), animals with 10-15years of age (83.00%) and in male (31.57%). Common predisposing factors were identified as frequent rubbing with trees, rope and metallic chain used for restraint, yoke used in draft animals, fences, barbed wire, manger protector and continuous ocular discharge. The most usual predilection sites of infection were the neck, withers or hump and ear. The characteristic clinical signs were the intense pruritis, ulcerated and non-ulcerated lesions with heavy accumulation of firm crusts. The remarkable histopathological changes were hyperkeratosis, the presence of cross and longitudinal section of parasites. Ivermectin showed the better response than that of the ointment applied locally.
