Objective: To investigate the efficacy and safety of a very low dose of isobaric bupivacaine with fentanyl for trans-abdominal/ vaginal oocyte retrieval for invitro fertilization in situations where it was difficult to access the oocyte through the vagina and would require anaesthesia. Design: setting. It is a prospective study that involved thirty-six adult females that presented at a fertility centre in Port-Harcourt Nigeria with difficulties to access oocytes through the vagina under sedation and had requirement for better relaxation under anaesthesia between August 2014 and January 2018. Methodology: Single shot spinal anaesthesia was administered using 5mg of isobaric bupivacaine with 25µg of fentanyl following written consent for regional anaesthesia. Results: All thirty-six women were successfully administered low dose spinal bupivacaine and fentanyl with ease of ultrasound guided trans-abdominal/ vaginal retrieval of oocytes withno obvious complications. Conclusion: Low dose spinal bupivacaine with fentanyl is a potent and safe technique for ambulatory trans-abdominal oocyte retrieval with very minimal complications.
