A study was conducted for two crop cycles to evaluate the efficiency of fungal endophytes against different phytopathogens of potato isolated from the leaf, stem, roots and tubers of Solanum tuberosum L. grown in South West Garo Hills district of Meghalaya. The endophytic fungal isolates were investigated in vitro against the selected phytopathogens of potato. Humicola fuscoatra recorded the highest percentage inhibition of 94.81% against Sclerotium rolfsii, followed by Penicillium canescens against Alternaria solani (93.33%), Trichoderma viride against S. rolfsii (93.33%), and T. viride against Fusarium solani (92.59%) and P. lanosum against F. solani (90%). Though all the isolates showed percentage of inhibition, H. grisea proved to be a good antagonist and showed maximum occurrence in suppressing the growth of A. solani (86.66%), Rhizoctonia solani (82.22%) and Phytophthora infestans (75.55%). The investigation revealed that the bioagents T. viride and H. grisea were able to inhibit the growth of the pathogen mycelia significantly.