This study was carried out to evaluate the effect of the hydro-methanol leaf extract of Bryophyllum pinnatum(family:Crassulaceae) on motor coordination and exploratory behaviour in mice weighing between 25-30g. The LD50 of the extract was calculated to be 400mg/kg and the various doses administered were 25mg/kg, 50mg/kg, and 100mg/kg. The parameters evaluated were the hole board test for explorative activity, beam-walking assay for motor coordination deficit. The results revealed that the extract showed a statistical significant (P<0.05) increase in the number of foot slips and beam latency at 25mg/kg and 50mg/kg. It also showed a decrease in head dips but was not significant.These results showed that the extract possesses some central nervous system (CNS) depressant activity which may be due to the effect or activity of one or more of the phytochemicals present in the plant.
