Plants are commonly used as herbal medicine because it contains various secondary metabolites such as alkaloids, flavonoids, saponins and terpenoid etc.Quercus infectoria and Terminalia chebula Retz. Were examined for their antibacterial activity against Methicillin Resistant Staphylococcus aureus. Antibacterial activity ofQuercus infectoria andT. chebula Retz. Was carried out by using the well diffusion method. Ethanol extract of T. chebula were more significant activity against MRSA compared with other solvents. Methanol extract of Q. infectoria showed highest zone of inhibition than other solvents. Minimum inhibitory Concentration of T. chebulawere observed at the ranges from <0.24 to 7.81 mg/ml for all extracts. MIC of theQ. infectoria were showed at the ranges from <0.24 to3.90 mg/ml. This results indicate that the both T. chebula and Q. infectoria have found greatest antibacterial activity against Methicillin Resistant Staphylococcus aureus.
