The present study was aimed to evaluate the growth inhibitory effect of Hibiscus rosasinensis, Azadirachta indica, Ficus religiosa and Ocimum sanctum leaves extracts on isolated fungi Aspergillus niger, Candida albicans, Cunnighamella bertholatiae and Penicillium sp.,. Aquous plant extracts were tested against 4 Fungi. Gel diffusion method, were used in this investigation. The Azadirachta indica medicinal plant extract 12 mm (Mean value in Dia.) were showed enormous antimicrobial activity against Aspergillus niger, Candida albicans and Cunnighamella bertholatiae. Ocimum sanctum medicinal plant extract showed the maximum zone of inhibition 12 mm (Mean value in Dia.) against Penicillium notatum. All the pathogenic fungi were more resistance to Ficus religiosa medicinal plant extract. The Azadirachta indica and Ocimum sanctum medicinal plants extracts were showed very promising antifungal activity.
