The present study was designed to evaluate adverse effects on biochemical and antioxidant parameters of testis in rats treated with aluminium chloride (AlCl3). Male Wistar rats were randomly divided into four groups. Rats of Group I received vehicle treatment while rats of Group II, III and IV were orally administered with AlCl3 at 30, 60 and 90 mg/kg b.wt/day respectively for 60 days. Half of the rats of Group IV were left untreated to observe reversibility of the adverse effects. Biochemical analysis showed a significant decline in the concentration of protein, sialic acid and in the activity of acid and alkaline phosphatase while the levels of total cholesterol and glycogen increased in a significant dose dependent manner in testis. AlCl3 treatment resulted in an increased level of lipid peroxidation (TBARs) whereas the activity of marker antioxidant parameters decreased as compared to control rats. In recovery group, after 60 days of treatment cessation, biochemical and antioxidant parameters restored which shows partial recovery. Results indicate that altered biochemistry as well as enhanced levels of free radicals and decreased antioxidants level may lead to deteriorative testicular function.
