Essential or primary hypertension (EH) is one of the major risk factors leading to mortality due to non-communicable disease. A complex interplay of genes along with lifestyle habits defines the pathophysiology of EH. Genome wide association studies (GWAS) and candidate gene studies (CGS) have provided details on the vital genes associated directly or indirectly with this disease phenotype. The present case control study was designed to analyze the association of PLEKHA and ULK4 gene polymorphisms in south Indian population. Subjects comprised of 568 hypertensive cases and 604 normotensive controls. A PCR-RFLP approach was applied to designate genotypes. Genotype and allele frequencies were compared between the normotensive and hypertensive groups. No significant association was recorded with each of the selected polymorphism in the population studied.
