Background: Menstruation is the discharge of blood and tissues from the lining of uterus each month. It is often called the menstrual period and is a function of the female body. Objective: This study was conducted to assess awareness of menstruation and related problems among Ayder high school adolescent girls, 2013. Methods: The study employed a cross-sectional design involving quantitative methods. The quantitative study was conducted on 259 students selected by simple random sampling technique from Mekelle high schools of Ayder female students. The data was collected using a self-administered questionnaire and analyzed using SPSS 16.0. Result: A total of 259 Female adolescent student of Ayder secondary school had participated in the study with a response rate of 99.2%. Majority age of the students 78 (30.1%) were 17 years with mean age 16.6±1.28. Most of the participants 254(98.1%) were follower of Orthodox Christianity and the remaining was Muslim. Conclusion and recommendation: The result indicates more than half of the respondents have awareness towards menstruation. Still the problem is not higher than the other study but in terms of time and severity, there is high problem related to menstruation. Ayder high school needs to form clubs to create awareness regarding menstruation to the female students. And Family to have free discussion before onset of pubertal changes and actions to be taken at its onset especially with menstruation
