Urinary tract infections (UTI) are one of the commonly encountered diseases in developing countries. This study determines the antibiotic resistance patterns of E.coli from Hospitalized UTI patients. Study was carried out in one year period. Among the E.coli isolates the resistance pattern was studied using the antimicrobial susceptibility pattern and using advanced expert system of Vitek 2 compact system. The resistant profile was analysed for Beta-lactam phenotypes and Amino glycosides phenotypes. In the Beta lactam phenotypes 62% of the isolates revealed ESBL and 8% of the isolates as Carbapenamase producers. Whereas in Amino glycosides phenotypes 35% accounts for aac (3) resistance and 50% of the isolates are wild types. This study was determined to understand the epidemiological resistant patterns in the isolated strains in the hospitalized patients. Antibiotic stewardship is becoming the growing trend in the health care systems to restrict the spread of multidrug resistant strain and to avoid the empirical treatment. This specific categorised statistical analysis will enhance the adherence of antibiotic policyin adult in with typical presentation.