The study is focused on the icthyotoxic activity of Momordica charantia leaf on African catfish, Clarias gariepinus, as well as its effect on water parameters. The erythrocyte count decreased from 1.80 to 1.08 while the leucocyte count increased from 4.04 to 5.91mm3 with increase in the level of Momordica charantia leaf in the fish feed. There is also decrease in haemoglobin count from 6.93 to 1.17gdl-1 with increase in the level of the powered leaf. These observations resulted in decrease in survival rate with increased level of the leaf in the fish feed. Water parameters like pH and alkalinity increased while dissolved oxygen decreased with increase in the level of the leaf in the fish feed. The overall effect is that incorporation Momordica charantia leaf in fish feed decreased the survival rate of Clarias gariepinus and this is concentration dependent.
