Livestock plays important role in household incomes especially on rural area of Nepal. During dry winter season, animal feed is in shortage by 36% in Nepal. Crop residue mainly rice straw, corn stover, wheat straw, millet straw, and other similar types of residues are used to feed these ruminant. These feed resources are very poor in nutrient contents. However, these feedstuffs can be improved in quality and utilized by supplementing with certain feed supplements such as urea molasses mineral block (UMMB). Objective of research is to find out the effect of UMMB supplement on milk yield, SNF%, fat%, lactose%, protein% and effect of Azadirachtaindica (“neem”) medicated UMMB supplementary feeding against nematode parasite performance in dairy buffaloes. The experimental trial was conducted in the livestock farm of Agriculture and Forestry University (AFU) and “Dhakal Dairy farm” from February, 2015 to April, 2015. 45 lactating crossbred buffaloes were selected for the experiment. Each animal were ear tagged for identification of animal. The research was conducted by using randomized complete block design in which three different treatments namely, T1= normal feeding + 500g UMMB + “neem” powder,T2= normal feeding + 500 g UMMB/day ,T3= on normal feeding (control). Based on milk production 45 lactating buffaloes were divided into 15 blocks. 3 treatments allocated in each block (RCBD). Mean milk yield (kg) and mean milk lactose of buffalo supplemented diet with UMMB was significantly effectiveness (P<0.05) was observed. Accordingly, higher milk production was recorded in diet supplement with UMMB (503.44 kg) treatment group. During 90 days of experimental period, there was an increment in milk production by 8.54% in medicated UMMB fed animal as compared to control group, which was statistically similar to non-medicated UMMB supplemented group, where increment was by 8.53 % as compared to control group. Dietary supplementation with UMMB of dairy buffaloes with medicated and non-medicated UMMB in two definite group increased milk yield and lactose significantly. On our study, Medicated UMMB blocks resulted in substantial reductions in fecal worm egg counts and increased milk yield in dairy buffaloes. The result indicated that the use of UMMB as a strategic feed supplement will be economically beneficial.