Present study reports the antioxidant activities of methanolic extracts of Psilotum nudum. The analyses carried out were DPPH radical scavenging activity, Reducing power assay, Ferrous ion chelating assay, ABTS•+ assay . From the analyses Psilotum nudum was found to have potent antioxidant activity against DPPH with IC50value of 118.81± 1.13. The value of reducing powerassay was 0.769± 0.001 and the value of Ferrous ion chelating assay was 196.28 ± 1.16. TheIC50value of ABTS•+ assay30.25± 0.51.Thus the result obtained in the present study that the plant have the potential as natural sources of antioxidant, capable of protecting against free radical damage and may have application in preventing and curing various diseases.