The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) has been a noninvasive tool used for decades to evaluate insulin resistance (IR) in clinical practice, as well as in large-scale, epidemiological studies. While standardized values have been established, we investigate whether HOMA-IR values fluctuate between different ethnic groups, and whether this has a direct impact on Systolic and Diastolic blood pressures. Thirty-nine studies were reviewed consisting of 68,965 total patients across 10 different ethnicities. A significant difference in HOMA-IR ranges were discovered between the ethnic groups, suggesting that this variable should be considered when using HOMA-IR to assess metabolic syndrome of insulin resistance and diabetes. Further investigation is needed to discover the underlying causes of these discrepancies and to more accurately identify HOMA-IR cut-off values for each ethnicity.
