Background: Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) are the most common manifestation of venous thrombosis. It is the third most common cardiovascular diseases and has fatal complications which can be prevented by application of prophylaxis measures according to American college of Chest Physician (ACCP), early detection and adequate treatment. Application of guidelines depends on the knowledge and attitude of practicing providers. Methods and Results: In this KAP Study we aimed to assess resident's knowledge, attitude and practice toward VTE prophylaxis. Structured questionnaire was used to assess 52 orthopedics registrars. The majority (88.5%) were male. Their age ranged from 23 to 32 year old with the mean 25.5 ± 4.3. 90% was not aware about the prevalence of DVT and 75% underestimated hospital mortality related to VTE. 55.8% didn't appreciate the safety of prescribing LMWH at home, While 65.4% of participants underestimated the importance of mechanical methods. 88.5% practiced VTE prophylaxis however 63% of them did it routinely. Low molecular weight heparin (LMWH) was used frequently by most of them. Although 42.3% were not aware about guidelines of VTE prophylaxis in orthopedic patients, the majority (75%) had accepted attitude level. Only 38.5% of participants were capable of identifying the high-risk patient. LMWH prescribed correctly by 86.5% of participants and the majority (71.2%) had moderate practice toward VTE prophylaxis. In conclusion Knowledge and attitude of orthopedic registrars regarding VTE was suboptimal and an education program should be designed and conducted on regular base to all residents and also for junior residents before starting their training program.