Breynia is a plant genus of the family Euphorbiaceae. Breynia have high medicinal importance and the selected species vitis-idaeais used traditionally to treat various diseases. The crude methanolic leaf extract of B. vitis-idaea was subjected to phytochemicalscreening for the presence of various phytochemicals. The present study was undertaken to analyze the chemical composition of methanolic crude extract from the leaves of B.vitis-idaea by using GC-MS. About28different compounds were reported. Also two important components Breynin A and Breyniaionoside A identified.