In this article, a search for antecedents’ latent variables of innovation from Strategic Talent Management Practices and Job Design for Indian Manufacturing industries was made. Structural Equation Modeling (SEM) was used to assess the fit of the model that identified Job Characteristics, Job Identity and Overall Job Design of employees as statistically significant antecedents of Innovation. Our models provided a good fit. Direct and Indirect effects of exogenous variables on endogenous variables estimated and resultant percent of variance accounted into Innovation reported. Limitation of the study, managerial implications and direction for future research discussed.