Novel 1-(4-substitutedphenyl)-3-(4-substitutedphenyl)-prop-2-en-1-oneswere synthesized from a Claisen-Schmidt reaction of4-substituted benzaldehyde with several acetophenone derivatives. Subsequently, the cyclocondensation reaction of chalcones with hydrazine gives5-(4-substitutedphenyl)-3-(4-substituted phenyl)-1H-pyrazole derivatives. Several of these compounds were screened for the ability as antibacterial and antifungal activity. Growth of S. aureus (gram positive), E.Coli (gram negative) bacteria and Candida albicans, Aspergillus niger are inhibit by the action on synthesized compounds.
