The objective of this study is to report a case of hypercalcemia secondary to two concomitant endocrinopathies. The case included a 34-year-old woman presented for nausea, vomiting, diarrhea and depression and found to have moderate hypercalcemia and hyperphosphatemia on laboratory tests. She was diagnosed with acute central adrenal insufficiency due to Sheehan syndrome, associated with hyperthyroidism secondary to overtreatment by thyroid hormones. She was successfully managed with hydration, stopping levothyroxine, and glucocorticoids with total resolution of her symptoms and normalization of calcium level. Central adrenal insufficiency and hyperthyroidism are rare causes of hypercalcemia and only few cases combine these 2 endocrine disorders.
