The conventional formulation route of administration is having the problem of drainage of instilled formulation, poor patient compliance as in the case of vaginal and rectal delivery system. The blurred vision and irritation to mucosa is observed in the case of ocular and nasal delivery also a big problem. Thus these problems force the researchers to find out another way to administration for such drugs. Several researchers are working to attain the therapeutic drug concentration at the intended site of action for sufficient period of time to elicit the pharmacological action. The most acceptable way for the administration of such drug has attained by formulating mucoadhesive and thermo reversible gel formulation for several drugs .The present work is focused to collect the reported researches for such drugs with special focus on Sertraline hydrochloride.
