A Study to “develop and evaluate the effectiveness Of Self Instructional Module on Mechanical Ventilators in terms of Knowledge and Skill of Staff Nurses working in Critical areas in selected Hospital of Delhi” was done in the year 2011-2012. The objectives of the study were: (1) To develop Self Instructional Module for the Staff Nurses on Mechanical ventilator. (2) To assess the knowledge and skill of Staff Nurses on Mechanical ventilator before and after administration of Self Instructional Module. (3) To determine the relationship between knowledge and skill of Staff Nurses on Mechanical Ventilator after the administration of the Self Instructional Module. (4)To see the acceptability and utility of Self Instructional Module on Mechanical Ventilator for the staff nurses of critical areas. The conceptual framework of the study was based on the System model for development, utilization and evaluation of self instructional module for the staff nurses. The model consists of three phases: Input, process and output in specific context including evaluation of all the phases (WHO SEARO, Technical Publications No. 6, 1985). The study adopted an evaluative research approach using one group pretest and post-test design. The independent variable of the study was the Self Instructional Module on Mechanical Ventilator. The dependent variables were the knowledge and skill of staff nurses on Mechanical Ventilator. The Self Instructional Module was developed based on the review of literature and non research literature, books and according to the objectives stated for the knowledge and skill. It was developed for enhancing the knowledge and skill of staff nurses regarding Mechanical Ventilator. The tools used for data collection were a structured questionnaire, observation checklist and a structured opinionnaire. The SIM and the data tools were prepared in simple English and were validated by eleven experts from the field of Medicine, Anesthesia, Surgery and Nursing field. The reliability of the knowledge questionnaire was established by calculating Kuder Richardson-20 formula. The reliability coefficient was found to be 0.80. The reliability of observation checklist, interobserver reliability was calculated by using rank order coefficient of correlation and it was found to be 0.99. The reliability of the opinionnaire was established by using Chronbach alpha formula and it was found to be 0.83. The Study was conducted at one of the renowed hospital in New Delhi. Multistage sampling technique was used to obtain the sample. The sample comprised of 60 staff nurses by total enumeration technique. Data were collected from 12th December 2011 to 31st December 2011 as per the research design. The data obtained was analyzed using both descriptive and inferential statistics in terms of frequency, percentage, mean, standard deviation, ‘t’ value and coefficient of correlation. The significant findings of the study were the mean post test knowledge scores of staff nurses were significantly higher than their mean pre test knowledge scores. The mean post test skill scores of the subjects were significantly higher than their mean pre test skill scores and there was a positive significant relationship existed between pre test and post test knowledge and skill scores of staff nurses. Thus the findings of the study revealed that Self Instructional Module was effective in enhancing the knowledge and skill of staff nurses regarding Mechanical Ventilator. On the basis of the study findings the following recommendations were made for the future research: 1. The study can be replicated on a large sample of staff nurses selected from various hospitals thereby the findings can be generalized for a large population. 2. A similar study can be conducted for the staff nurses working in general areas to test the effectiveness of Self Instructional Module on Mechanical Ventilator. 3. A study can be done to assess the attitude of nursing personnel and trained Emergency Medical Technician towards the need for developing knowledge and skill in using Mechanical Ventilator. 4. Other teaching strategies i.e. planned teaching programme, guidelines etc can be used to assess the Knowledge and Skill of staff nurses on Mechanical Ventilator. 5. A study can be undertaken to ascertain the patient’s health status outcome who is on long term ventilator support in relation to nursing care. 6. A comparative study can be used to find out the survival rate in both private and public hospitals.