Field experiment was conducted on sweet sorghum to study the evaluation of inorganic fertilizer, organic manures, biofertilizers and micronutrients on soil properties at Experimental Farm, Annamalai University during season of summer 2009. The experimental field consisted of chemical fertilizer, vermicompost, biofertilizer (Azospirillum + Phosphobacteria) and micronutrient (Zn and Mn). The result shows that application of 75% RDF + Vermicompost + Biofertilizers (T7) had registered higher grain yield, stalk yield, total biomass and dry matter, compared to rest of the treatments.