Field investigation was conducted at the experimental farm at Annamalai University, Annamalai Nagar to study the influence of integrated Nutrient management practices on the growth and yield of sorghum during summer 2009. The experiments were laid out in randomized block design with ten treatments with replicated thrice. The results shows that application of 100 per cent recommended dose of NPK fertilizers with vermicompost @ 5 t ha-1 and soil application of Azospirillum @ 2kg ha-1 followed by 75 percent recommended dose of NPK fertilizers along with vermicompost @ 5 t ha-1 + soil application of Azospirillum @ 2kg ha-1. It also recorded the highest grain yield of 2352.00 kg ha-4 and the highest return per rupee invested of 2.31 in 2013. The uptake of N,P and K was also the highest with the above treatment combination. The least yield and uptake of nutrients by crop was noticed under 75 per cent recommended crop was noticed under 75 percent recommended dose of NPK fertilizers in 2013.