Laser resurfacing.mechanical resurfacing and chemical peels for dilated follicular orifices (DFO), depressive acne scarsandfacial wrinkles may provoke a downtime including purpura and crust, and side effects such as postinflammatory hyperpigmentation (PIH), mottled hypopigmentation and scarring. To investigate the efficacy and safety of a785nm picosecond laser treatment for DFO, depressive acne scars and facial wrinkles, this study was performed. Six Korean patients with DFO, seven Korean patients with depressive acne scars and seven Korean patients with facial wrinkles were treated with a 785nm picosecond laser at a 2-week interval for 10 treatment sessions. The parameters were a spot size of 4 mm, a fluence of 0.7 J/cm2, a pulse duration of 300 picoseconds and a pulse rate of 5Hzwith 3 passes including 3000 shots by a sliding technique over the entire face. At the week of the final treatment, six patients with DFO, seven patients with depressive acne scars and seven patients with facial wrinkles were achieved the good improvement(more than 50% but less than 75%)without any side effects such as purpura, crust, PIH, mottled hypopigmentation and scarring. A 785 nm picosecond laser treatment is a safe and effective method without side effects for DFO, depressive acne scars and facial wrinkles.