Peptic ulcer disease (PUD) is considered as one of the common diseases in the world. Modern allopathic drugs are used in the treatment of peptic ulcer but most of these drugs exhibit serious side effects. Medicinal plants containing active chemical constituents are useful in prevention and treatment of various diseases. Herbal medicines are considered as better alternatives for the treatment of peptic ulcer. To review the medicinal plants which are used in the treatment or prevention of Peptic Ulcer Diseases used in Siddha Medicine and the other reported activities like phytochemical compounds and traditional uses of these plants. Cocculus hirsutus, Basella rubra, Hemidesmus indicus, Cissus quadrangularis, Solanum nigrum are frequently used all over the world as medicinal plants for the treatment of peptic ulcer diseases.
